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| Product Name | Frizzled 10, Fc Chimera, Recombinant, Human (FZD10) |
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| Description | Purity ≥90% by SDS-PAGE under reducing conditions and visualized by silver stain. Frizzled 10 is a 68kD seven pass transmembrane glycoprotein in the Frizzled family of Wnt receptors. The 205 amino acid N-terminal extracellular region of Frizzled 10 contains a cysteine-rich domain that comprises the Wnt binding domain and mediates receptor oligomerization. The C-terminal cytoplasmic tail contains a PDZ-interaction motif. PDZ motifs mediate intracellular binding to scaffolding proteins. Within the cysteine-rich domain, human Frizzled 10 shares 71% amino acid (aa) sequence identity with Frizzled 9 and 31%-46% with Frizzled 1, -2, -3, -4, -5, -6, -7 and -8. It shares 96%, 94%, 90%, and 82% aa sequence identity with chick, mouse, Xenopus and zebrafish Frizzled 10, respectively. Frizzled 10 is expressed during embryogenesis in the primitive streak, dorsal neural tube, developing brain, limb bud and airway epithelium. It is induced by Shh and colocalizes with Shh and Wnt-7a in the neural tube |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q6NSL8 |
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| Catalog # | F6401-47 |
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| Order / More Info | Frizzled 10, Fc Chimera, Recombinant, Human (FZD10) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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