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| Product Name | Frizzled-9, Fc Chimera, Recombinant, Mouse, aa24-186 (Frizzled Family Receptor 9, CD349, FZD9) |
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| Description | Purity ~95% (SDSPAGE). Frizzled-9 (Fzd9, previously called Fzd3) belongs to the Frizzled family of seven-transmembrane glycoprotein receptors, which are signaling receptors for the family of secreted Wnt ligands (1-3). Mouse Frizzled-9 cDNA encodes 592 amino acids (aa) including a 23aa signal peptide, a 207aa extracellular domain (ECD), the 7TM region (aa231-530), and a C-terminal cytoplasmic domain with a PDZ binding motif. The ECD includes a cysteine-rich region (CRD, aa35-156) that binds Wnts and is highly conserved among Frizzleds. Within aa23-186, mouse Frizzled9 shares 100%, 97%, 97% and 96% aa identity with rat, human, canine and bovine Frizzled9, respectively. The human Frizzled-9 gene is within a large region that is deleted in Williams-Beuren syndrome, a developmental disorder affecting personality and cognition (2). Frizzled-9 mRNA is expressed in the mouse central nervous system and myotomes during development, and persists in the hippocampus throughout life (2-4). Adult |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q9R216 |
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| Catalog # | 145790 |
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| Order / More Info | Frizzled-9, Fc Chimera, Recombinant, Mouse, aa24-186 (Frizzled Family Receptor 9, CD349, FZD9) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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