| 产品详情 |
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| Product Name | ML 141 |
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| Description | Purity >98%. Cdc42 is a member of the Rho GTPase subfamily that has roles in cytoskeleton organization, cell cycle progression, signal transduction, and vesicle trafficking. It cycles between a GTP-bound active state and a GDP-bound inactive state. ML 141 is a noncompetitive, allosteric inhibitor of Cdc42 (EC50 = 2.1 µM) with no inhibitory action against Rho, Ras, Rab, or Rac. It also inhibits the constitutively active Cdc42 Q61L mutant (EC50 = 2.6 µM). ML 141 blocks Cdc42-dependent filopodia formation in 3T3 cells and migration of ovarian cancer cells, prevents Cdc42-regulated virus infection, and inhibits the signaling pathway of VLA-4 integrin. It is a useful tool to interrogate the role of Cdc42 intracellular signaling and cell activity. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[4,5-dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-benzenesulfonamide, CID2950007 |
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| Gene, Accession, CAS # | CAS: 71203-35-5 |
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| Catalog # | LS-H8721 |
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| Price | |
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| Order / More Info | ML 141 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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