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| Product Name | ML167 |
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| Description | Purity >98%. The Cdc2-like kinases (Clks) and the dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) are involved in regulating gene splicing. Clks phosphorylate serine/arginine-rich proteins, which are a major component of the spliceosome, whereas DYRKs interact with and activate splicing factors. ML167 is a selective, ATP-competitive inhibitor of Clk4 with an IC50 value of 136 nM. It is more than 10-fold less active against the closely related kinases Clk1-3, DYRK1A, and DYRK1B (IC50 s = 1.5, 1.6, >10, >10, and 4.4 µM, respectively), and minimally active against a panel of other kinases. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5-[4-[[(5-methyl-2-furanyl)methyl]amino]-6-quinazolinyl]-2-furanmethanol, CID 44968231 |
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| Gene, Accession, CAS # | CAS: 1285702-20-6 |
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| Catalog # | LS-H8731 |
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| Price | |
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| Order / More Info | ML167 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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