| 产品详情 |
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| Product Name | Eliprodil |
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| Description | Purity >98%. N-Methyl-D-aspartate (NMDA) receptors are calcium permeable ligand-gated channels of the central nervous system that are activated after binding of the co-agonists glutamate and glycine. Eliprodil is a non-competitive NMDA receptor antagonist that inhibits neuronal calcium channel currents. It is selective for NR2B subunit-containing receptors (IC50 = 1 µM), displaying greater than 100-fold selectivity for NR2B over NR2A and NR2C subunits. Eliprodil also avidly binds s1 and s2 sites (Ki s = 0.013 and 0.63 µM, respectively). It is effective in vivo, blocking ischemia-induced neurodegeneration in the CA1 region of the hippocampus of gerbils subjected to bilateral carotid artery occlusion. Eliprodil can also have proarrhythmic actions in hearts under normal conditions. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | a-(4-chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol, SL 820715 |
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| Gene, Accession, CAS # | CAS: 119431-25-3 |
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| Catalog # | LS-H7643 |
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| Order / More Info | Eliprodil from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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