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| Product Name | DCBLD2, Recombinant, Human, aa67-528 |
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| Description | Purity ~95% (SDS-PAGE). DCBLD2 (discoidin, CUB, and LCCL domain containing protein 2), also known as CLCP1 and ESDN, is a 100130kD glycoprotein that bears structural resemblance to the Neuropilin family of molecules. Mature human DCBLD2 is a type I transmembrane protein that consists of a 462 amino acid (aa) extracellular region (ECD), a 21 aa transmembrane segment, and a 226 aa cytoplasmic domain (1, 2). Within the ECD, human DCBLD2 shares ~88% aa sequence identity with mouse and rat DCBLD2. Alternative splicing generates an isoform that contains a 14 aa insertion in the cytoplasmic domain. DCBLD2 is expressed on vascular smooth muscle cells (VSMC), particularly in regions of arteriosclerosis and vascular injury (2, 3). It is upregulated on PDGFBB stimulated VSMC and inhibits PDGFBB induced VSMC proliferation and migration (24). It is also expressed on platelets and inhibits clot formation in a zebrafish model of thrombosis (5). Compared to normal tissue, DCBLD2 expression is dow |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | DCBLD2, Recombinant, Human, aa67-528 (CLCP1, ESDN, Iscoidin, CUB, LCCL Domain Containing Protein 2, Endothelial and Smooth Muscle Cell-derived Neuropilin-li) |
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| Gene, Accession, CAS # | SwissProt: Q96PD2 |
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| Catalog # | 145786 |
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| Order / More Info | DCBLD2, Recombinant, Human, aa67-528 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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