| 产品详情 |
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| Product Name | MRT67307 |
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| Description | Purity >95%. MRT67307 is a kinase inhibitor that has been shown to inhibit TBK1, MARK1-4, IKKe, and NUAK1 (IC50 values are 19, 27-52, 160, and 230 nM, respectively), the salt-inducible kinases (SIKs; IC50 s = 250, 67, and 430 nM for SIK1, SIK2, and SIK3, respectively) and ULK1 and ULK2 (IC50 s = 45 and 38 nM, respectively). MRT67307 prevents the phosphorylation of IRF3 and the production of IFN-Beta and increases toll-like receptor-induced IL-10 and IL-1ra secretion in macrophages. Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[3-[[5-cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]-cyclobutanecarboxamide |
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| Gene, Accession, CAS # | CAS: 1190378-57-4 |
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| Catalog # | LS-H8817 |
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| Price | |
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| Order / More Info | MRT67307 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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