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| Product Name | Polymerase Cofactor VP35, Recombinant, Zaire Ebolavirus, aa1-340, His-tag, Myc-tag (VP35) |
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| Description | Purity ~85% (SDS-PAGE). Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. This blockage is produced through the interaction with and inhibition host IKBKE and TBK1 producing a strong inhibition of the phosphorylation and activation of IRF3. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR. Source: Recombinant protein corresponding to aa1-340 from Zaire ebolavirus Polymerase Cofactor VP35, fused to His-tag at N-terminal and fused to Myc-tag at C-terminal, expressed in E. coli. Molecular Weight: ~42.4kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q6V1Q9 |
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| Catalog # | 406024 |
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| Order / More Info | Polymerase Cofactor VP35, Recombinant, Zaire Ebolavirus, aa1-340, His-tag, Myc-tag (VP35) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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