| 产品详情 |
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| Product Name | Spautin-1 |
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| Description | Purity ~99% (HPLC). A quinazolin compound that acts as a specific and potent inhibitor of autophagy and promotes Vps34 PI 3-kinase complex degradation by blocking the activity of USP 10 (IC50 = 580nM) and USP 13 (IC50 = 690nM) deubiquitinating enzymes. However, it does not affect the lipid kinase activity of Vps34. Also shown to reduce the level of cytoplasmic and nuclear p53. Sensitizes breast cancer cell lines (BCAP37, MCF-7, and BT549) to apoptosis under conditions of nutritional deprivation. Also shown to inhibit etoposide-induced cell death in Bax/Bak double knockout (DKO) cells. Normal cell lines (e.g., MDCK cells) do not undergo autophagy in the presence of Spautin-1. Formula: C15H11F2N3 Molecular Weight: 371.3 Solubility: DMSO (50mg/ml, clear, colorless solution) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Spautin-1 (6-fluoro-N-[4-fluorobenzyl]quinazolin-4-amine, Specific and Potent AUtophagy Inhibitor 1, C43, Autophagy Inhibitor II) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217803 |
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| Price | |
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| Order / More Info | Spautin-1 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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