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| Product Name | Spautin-1 |
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| Description | Purity >95%. Spautin-1 is an autophagy inhibitor, inducing cell death in human breast cancer Bcap-37 cells grown in glucose-free media (EC50 = ~1.25 µM). It does not significantly affect the viability of Bcap-37 cells grown in complete media. Spautin-1 promotes the degradation of Vps34 PI3K complex by inhibiting the deubiquitinating enzymes USP10 and USP13 (IC50 s = 0.58 and 0.69 µM, respectively). It is used to elucidate the role of autophagy in cellular processes. Spautin-1 has also been used to demonstrate roles for autophagy in viral infection. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 6-fluoro-N-[(4-fluorophenyl)methyl]-4-quinazolinamine |
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| Gene, Accession, CAS # | CAS: 1262888-28-7 |
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| Catalog # | LS-H9981 |
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| Order / More Info | Spautin-1 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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