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| Product Name | Spautin-1 |
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| Description | Purity >98% by NMR, TLC. Spautin-1 is a specific and potent autophagy inhibitor. Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin-specific proteases USP10 and USP13 which target the Beclin-1 subunit of Vps34 complexes. Deranges dengue virion maturation. Spautin-1 inhibits autophagy in a Beclin-1 independent manner in primary epithelial ovarian cancer cells. Selectively induces cell death of mutant p53-expressing cancer cell lines under confluency. Cell permeable. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 6-Fluoro-N[(4-fluorophenyl)methyl]-4-quinazolinamine |
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| Gene, Accession, CAS # | CAS: 1262888-28-7 |
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| Catalog # | LS-H14851 |
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| Order / More Info | Spautin-1 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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