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| Product Name | FLASH, CT, Blocking Peptide (FLICE-associated Huge Protein) |
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| Description | Purified 60-70%. Peptide (SERFQQLMKLFEKSKC) corresponding to amino acids 1253 to 1268 of human origin, which differ from those of mouse by one amino acid (1,2). A novel mammalian CED-4 homologous was recently identified and cloned in mouse (1) and human (2) and designated FLASH (for FLICE-associated huge protein). FLASH is involved in Fas induced apoptosis. It is recruited to Fas after the receptor cross-linking. Overexpression of wild type of FLASH facilitates and its dominant negative form inhibits Fas induced apoptosis. FLASH interacts with the DEDs of caspase-8 and FADD through the DED-like domain of FLASH and mediates activation of caspase-8 (1). There are parallels between FLASH and Apaf-1/CED-4 although there are arguments against their structural similarity (1,2). FLASH is widely expressed. Applications: Suitable for use in ELISA, Western Blotting. Positive Control: HeLa whole cell lysate |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | ELISA WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | F4538P |
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| Order / More Info | FLASH, CT, Blocking Peptide (FLICE-associated Huge Protein) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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