| 产品详情 |
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| Product Name | BAY 11-7082 |
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| Description | MW: 207.3. Purity >98% (TLC: 1:9, CH3OH:CH2Cl2; Rf=0.6); NMR (Conforms). IKK inhibitorInhibits cellular necroptosis a non-apoptotic cell death pathway which leads to necrosis (EC50 = 494 nM)1. Inhibits receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM) the key upstream kinase in the necroptosis activation pathway2,3. Reduces ischemic brain injury in a mouse model of stroke1 and inhibits myocardial death4.Scientific Background: Inhibits cytokine -induced IkB-alpha ph |
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| Size | 10 mg, 50 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [Necrostatin ; 5-(1H-Indol-3-ylmethyl)-3-methyl-2-~thioxo-4-imidazolidinone; Methylthiohydantoin-DL-tryptophan; (E)-3-[(4-methylphenylsulfonyl]-2-propenenitrile] |
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| Gene, Accession, CAS # | CAS: 19542-67-7 |
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| Catalog # | MBS515014 |
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| Order / More Info | BAY 11-7082 from MYBIOSOURCE INC. |
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| Product Specific References | 1. A Degterev et al. Nat. Chem. Biol. 2005 1:112 2. A Degterev et al. Nat. Chem. Biol. 2008 4:313 3. A Linkermann et al. Kidney Int. 2012 81:751 4. CC Smith et al. Cardiovasc. Drugs Ther. 2007 21:227 |
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