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| Product Name | Okadaic Acid, Prorocentrum sp. (OA) |
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| Description | Purity ~95% (HPLC). An ionophore-like polyether derivative of a C38 fatty acid compound that has tumor promoting properties. Potent inhibitor of protein phosphatase 1 (IC50=10-15nM) and protein phosphatase 2A (IC50=0.1nM). Does not affect the activity of tyrosine phosphatases, alkaline phosphatases, or acid phosphatases. Useful for the study of protein phosphatases in cell extracts as well as in intact cells. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF7) and in myeloid cells but inhibits glucocorticoid-induced apoptosis in T cell hybridomas. Has marked contractile effects on smooth muscle and heart muscle. Implicated as causative agent of diarrhetic shellfish poisoning. Formula: C44H68O13 Primary Target: Protein phosphatase Primary Target IC50: 10-15nM Secondary Target: Protein phosphatse 2A (IC50 = 0.1nM) Solubility: MeOH, EtOh, DMF, CHCl3 Molecular Weight: 805 |
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| Size | 25ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217608 |
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| Price | |
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| Order / More Info | Okadaic Acid, Prorocentrum sp. (OA) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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