| 产品详情 |
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| Product Name | HIPK2, Recombinant, Mouse, GST-Tag (Stank, 1110014O20Rik, B230339E18Rik) |
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| Description | Purified (~70-90%). HIPK2 is a conserved serine/threonine nuclear kinase that interacts with homeodomain transcription factors. HIPK2 enhances expression of p53 target genes that resulting in growth arrest and the enhancement of UV-induced apoptosis that could be inhibited by antisense to HIPK2. HIPK2 as a target for MDM2 mediated ubiquitin-dependent degradation that only occurred in growth-arresting conditions when MDM2 was efficiently induced by p53. The knockdown of HIPK2 using small interfering RNA reduced p53 binding and activation of p53R2 that resulting in impaired UV-induced DNA repair. Source: Recombinant protein corresponding to mouse HIPK2 fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~72kD Specific Activity: 110nmol/min/mg as per activity assay protocol. |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: BC031904 |
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| Catalog # | 500068 |
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| Order / More Info | HIPK2, Recombinant, Mouse, GST-Tag (Stank, 1110014O20Rik, B230339E18Rik) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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