| 产品详情 |
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| Product Name | PIT-1 |
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| Description | Purity >98% by NMR, TLC. PIT-1 is a PH domain antagonist. Specifically blocks the binding of PIP3 to the Akt pleckstrin homology domain (IC50 = 31 mM). Suppresses PI3K-PDK1-Akt-dependent phosphorylation. Induces apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 mM). Inhibiting the binding of PIP3 to effector PH domains is new point of intervention in the PI3K signaling network. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide |
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| Gene, Accession, CAS # | CAS: 53501-41-0 |
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| Catalog # | LS-H14805 |
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| Order / More Info | PIT-1 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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