| 产品详情 |
| Edit |   |
|---|
| Product Name | PIT-1 |
|---|
| Description | Purity >98%. PtdIns-(3,4,5)-P3 (PIP3 ) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as phosphatidylinositol 3-kinase (PI3K) or PTEN. Protein binding to PIP3 is important for cytoskeletal rearrangement and membrane trafficking and initiates an intricate signaling cascade that has been implicated in cancer. PIT-1 is a selective nonphosphoinositide inhibitor that specifically disrupts PIP3 /Akt PH domain binding with an IC50 value of 31 µM. PIT-1 suppresses PI3K-PDK1-Akt-dependent phosphorylation, which has been shown to reduce cell viability and induce apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 µM). |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | N-[[(3-chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]-benzamide |
|---|
| Gene, Accession, CAS # | CAS: 53501-41-0 |
|---|
| Catalog # | LS-H9439 |
|---|
| Price | |
|---|
| Order / More Info | PIT-1 from LIFESPAN BIOSCIENCES INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|