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| Product Name | Prion Protein, aa106-126, Human (PrP, CD230) |
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| Description | Purity ~95%. Purified by HPLC. Synthetic peptide from human Prion Protein, aa106-126. Sequence (linear): Lys-Thr-Asn-Met-Lys-His-Met-Ala-Gly-Ala-Ala-Ala-Ala-Gly-Ala-Val-Val-Gly-Gly-Leu-Gly Prions are large cell membrane-anchored glycoproteins that are normally localized to the presynaptic membrane of neurons in mammalian brain. Prions are likely to be involved in synaptic transmission. In prion diseases, such as Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler-Scheinker syndrome (GSS), Fatal Familial Insomnia (FFI), Alpers Syndrome, and Kuru, the normal cellular form of this protein (PrPc) is transformed into an altered, proteolysis-resistant form upon coming into contact with an infectious prion protein (PrPsc) from another host. This altered prion protein accumulates in cytoplasmic vesicles of diseased individuals, forming lesions, vacuoles, and amyloid deposits. This antiserum can routinely be used without further purification. |
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| Size | 1mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Lys-Thr-Asn-Met-Lys-His-Met-Ala-Gly-Ala-Ala-Ala-Ala-Gly-Ala-Val-Val-Gly-Gly-Leu-Gly |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | P8950-08 |
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| Order / More Info | Prion Protein, aa106-126, Human (PrP, CD230) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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