| 产品详情 |
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| Product Name | eIF2-GTP-tRNAiMet Ternary Complex Inhibitor, BTdCPU |
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| Description | Purity ≥99% (HPLC). A cell-permeable N,N'-diarylurea that acts as an inhibitor of the formation of the ternary complex of eukaryotic translation initiation factor 2 (eIF2), GTP and the initiator methionine tRNA (Met-tRNAi), a key regulatory step of translation initiation. It directly activates heme-regulated inhibitor kinase (HRI), which then phosphorylates eIF2a in cells at 10uM and in cell-free extracts dose-dependently, and thereby prevents respective ternary complex formation without elevating oxidative stress. The sensitivities of various cancer cell lines to the anti-proliferative effects of this compound are shown to correlate with the expression of HRI. Furthermore, this compound displays tumor growth inhibition in a mice xenograft model of MCF-7 human breast cancer cells at 175mg/kg, in vivo. CAS No: 1257423-87-2 |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | eIF2-GTP-tRNAiMet Ternary Complex Inhibitor, BTdCPU (N,N'-diarylurea;translation Initiation Tenrary Complex Inhibitor, 1-(benzo[d][1,2,3]thiadiazol-6-yl)-3-(3,4-dichlorophenyl)urea, BTdCPU, Heme-regulated Inhibitor Kinase Activator, BTdCPU) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217337 |
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| Order / More Info | eIF2-GTP-tRNAiMet Ternary Complex Inhibitor, BTdCPU from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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