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| Antigenic Specificity | Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) |
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| Clone | 5H9 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | supernatant |
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| Size | 1 mL |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunohistochemistry (Frozen Sections) (IHC (fro)),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)),Immunocytochemistry (ICC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Cadherins constitute a family of transmembrane glycoproteins involved in Ca2+-dependent cell-cell interactions. The members of this family are differentially expressed in various tissues. They function in the maintenance of tissue integrity and morphogenesis. Cadherins are divided into type I and type II subgroups. Type I cadherins include epithelial cadherin (E-cadherin, cadherin-1 or uvomorulin), neural cadherin (N-cadherin or cadherin-2), placental cadherin (P-cadherin or cadherin-3) and retinal cadherin (R-cadherin or cadherin-4), whereas kidney cadherin (K-cadherin or cadherin-6) and osteoblast cadherin (OB-cadherin or cadherin-11) are type II cadherins. One of the best characterized cadherins is E-cadherin, a 120 kD transmembrane glycoprotein consisting of an 80 kD extracellular and a 40 kD transmembrane and cytoplasmic part. The extracellular domains of E-cadherin are responsible for calcium binding which allows for homophilic interaction with other E-cadherin molecules on the same cell and neighbouring cells. In addition, E-cadherin can interact heterophilically with integrin i!Eic7. The cytoplasmic domain of E-cadherin is linked to the actin cytoskeleton through the associated cytoplasmic catenin proteins, thus establishing a complex localized to adherens junctions. In carcinomas E-cadherin is frequently downregulated, which is consistent with its function of an invasion suppressor in normal epithelia. |
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| Immunogen | 5H9 is a mouse monoclonal IgG1 antibody obtained by fusion of P3-X63-Ag 8,653 mouse myeloma cells with spleen cells from a BABL/c mouse immunized with affinity purified 80 kD extracellular fragments of E-cadherin derived from tryptic digestion of A-431 human vulva carcinoma cells. |
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| Other Names | E-Cad|E-cadherin|XB-cadherin|XBcad|XTCAD-1|b-cadherin|cadherin-1|cdh1-a|cdhc-A|cdhp|hjmd|l-cam|lcam|pcad|uvo|uvomorulin|xb-cad|xcdh1|Arc1|AA960649|E-cad|Ecad|L-CAM|UVO|Um|Arc-1|CD324|CDHE|ECAD|LCAM|arc-1|cd324|cdhe|ecad|cdh1|si:dz180o5.2 |
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| Gene, Accession # | Gene ID: 999 |
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| Catalog # | ABIN459321 |
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| Order / More Info | Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 2007622, 8256859, 8682585, 9504862 |
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