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| Antigenic Specificity | Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) |
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| Clone | 7H12 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse, monkey |
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| Isotype | IgG1 |
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| Format | ascites |
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| Size | 0.1 mL |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),ELISA |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calciumdependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues.Synonyms: UVO, CDHE, ECAD, LCAM, Arc-1, CD324, CDH1 |
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| Immunogen | Purified recombinant fragment of human CDH1 expressed in E. Coli. |
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| Other Names | E-Cad|E-cadherin|XB-cadherin|XBcad|XTCAD-1|b-cadherin|cadherin-1|cdh1-a|cdhc-A|cdhp|hjmd|l-cam|lcam|pcad|uvo|uvomorulin|xb-cad|xcdh1|Arc1|AA960649|E-cad|Ecad|L-CAM|UVO|Um|Arc-1|CD324|CDHE|ECAD|LCAM|arc-1|cd324|cdhe|ecad|cdh1|si:dz180o5.2 |
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| Gene, Accession # | Gene ID: 999,12550 |
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| Catalog # | ABIN965838 |
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| Price | |
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| Order / More Info | Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 19915572, 18608415, 20026874 |
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