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| Product Name | ROS1, Active, Recombinant, Human, GST-Tag |
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| Description | Purified (~55%). ROS1 is an orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. Source: Recombinant corresponding to aa1883-2347 from human ROS1, fused to GST-tag at N-terminal, expressed in Sf9 cells via a baculovirus expression system. Molecular Weight: ~78kD Applications: Suitable for use in the study of enzyme kinetics, screenin |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ROS1, Active, Recombinant, Human, GST-Tag (Proto-oncogene Tyrosine-protein Kinase ROS, Proto-oncogene c-Ros, Proto-oncogene c-Ros-1, Receptor Tyrosine Kinase c-ros Oncogene 1, c-Ros Receptor Tyrosine Kinase, MCF3, ROS) |
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| Gene, Accession, CAS # | Accession: NM_002944 |
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| Catalog # | 137365 |
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| Order / More Info | ROS1, Active, Recombinant, Human, GST-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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