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APRIL, Recombinant, Mouse (A Proliferation-inducing Ligand, CD256, TALL2, TNFSF13, TRDL1, ZTNF2) from UNITED STATES BIOLOGICAL |
| 产品详情 |
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| Product Name | APRIL, Recombinant, Mouse (A Proliferation-inducing Ligand, CD256, TALL2, TNFSF13, TRDL1, ZTNF2) |
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| Description | Purity ~95% (SDS-PAGE). APRIL (a proliferationinducing ligand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF ligand superfamily (1). It is synthesized as a 32kD proprotein which is cleaved by furin in the Golgi to release the active 17kD soluble molecule (24). Secreted mouse APRIL, which consists almost entirely of a single TNF homology domain, shares 85% and 95% amino acid sequence identity with human and rat APRIL, respectively (2, 3). Both APRIL and its close relative BAFF bind and signal through the TNF superfamily receptors TACI and BCMA, while BAFF additionally functions through BAFF R (2, 5, 6). APRIL binds to heparan sulfate proteoglycans (HSPGs) independently of its binding to TACI and BCMA (6, 7). The interaction with HSPGs induces APRIL oligomerization, and this augments TACI, or BMCAmediated effects (7, 8). HSPGs are also critical for the tumor growthpromoting effects attributed to APRIL (6). APRIL can form bioactive heterotrimers with BAFF, a |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NP_001152977 |
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| Catalog # | 167626 |
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| Order / More Info | APRIL, Recombinant, Mouse (A Proliferation-inducing Ligand, CD256, TALL2, TNFSF13, TRDL1, ZTNF2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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