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| Product Name | TCF7L2, Recombinant, Human, aa1-456, His-Tag (Transcription Factor 7-like 2) |
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| Description | Purity ~90% (SDS-PAGE). Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. Source: Recombinant protein corresponding to aa1-456 from human TCF7L2, fused to His-Tag at N-terminal expressed in E. coli. Molecular Weight: ~54.9kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | HMG box transcription factor 4, T-cell-specific transcription factor 4, T-cell factor 4,TCF-4, hTCF-4 |
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| Gene, Accession, CAS # | SwissProt: Q9NQB0 |
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| Catalog # | 375508 |
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| Order / More Info | TCF7L2, Recombinant, Human, aa1-456, His-Tag (Transcription Factor 7-like 2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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