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| Product Name | DnaK, Recombinant, E. coli |
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| Description | Purity ≥ 95% as determined by SDS-PAGE analysis. DnaK is an acidic 70kD Escherichia coli heat shock protein which belongs to the molecular chaperone class of proteins (1). The sequence of the dnaK gene is highly homologous with eukaryotic Hsp70 proteins. Reversible binding of Hsp70 to unfolded nascent polypeptides, partially denatured proteins and also some native proteins leads to: i) the stabilization of polypeptide chains during de novo folding, ii) protection of other proteins from aggregation, iii) reactivation of heat inactivated enzymes, iv) promotion of peptide translocation through membranes, and v) exposure of partially denatured proteins for efficient proteolysis. The N-terminal domains of Hsp70 proteins contain an ATPase active site, and the C-terminal domains contain a peptide binding site. DnaK has been shown to bind to various aberrant proteins including protein fragments, mutant proteins, unfolded proteins as well as native proteins: lambdaP, lambdaO and sigma32. DnaK's |
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| Size | 50ug, 200ug |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P0A6Y8 (strain K12) |
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| Catalog # | D4015-11 |
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| Order / More Info | DnaK, Recombinant, E. coli from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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