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| Product Name | LAIR1, Recombinant, Human, aa22-163, His-Tag |
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| Description | Purity ~95% (SDS-PAGE). LAIR1 (leukocyte-associated Ig-like receptor-1, designated CD305) is an ~40kD type I transmembrane inhibitory glycoprotein belonging to the Ig superfamily (1-4). LAIR1 is a collagen-binding protein that is expressed in a differentiation- and activation-dependent manner on most immune cells, including T, B, NK and dendritic cells (DC), monocytes, CD34+ hematopoietic progenitors, most thymocytes, and selected granulocyte populations (2-7). Mature human LAIR1 is a 266 amino acid (aa) type I transmembrane protein that includes a 144aa extracellular domain (ECD) with one collagen-binding C2-type Ig-like domain, and a 101aa cytoplasmic domain with two ITIM motifs (2, 3, 8, 9). Of four potential human LAIR1 splice variants, LAIR1b has a 17aa deletion within the ECD, but outside the Ig domain. LAIR1c differs from LAIR1b by one aa. LAIR1d has a 78 aa cytoplasmic truncation and lacks ITIM motifs. Human LAIR1 ECD shares <45% aa sequence identity with mouse, rat, bovine or |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | LAIR1, Recombinant, Human, aa22-163, His-Tag (CD305, Eukocyte-associated Ig-like Receptor-1, Designated CD305) |
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| Gene, Accession, CAS # | SwissProt: Q6GTX8 |
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| Catalog # | 145816 |
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| Order / More Info | LAIR1, Recombinant, Human, aa22-163, His-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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