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| Product Name | LAIR-1, Recombinant, Mouse (Leukocyte-associated Ig-like Receptor-1) |
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| Description | Purity ≥ 90%, as determined by SDS-PAGE and visualized by silver stain. Leukocyte-associated Ig-like receptor-1 (LAIR-1) is an inhibitory receptor of the Ig superfamily that is structurally related to inhibitory members of KIR and ILT/CD85 families (1-3). It is expressed on immune cells, including NK cells, T cells, B cells, monocytes, immature neutrophils, dendritic cells and most thymocytes (2-4). The 253 amino acid (aa) type I transmembrane (TM) protein contains a 21 aa signal sequence, a 124 aa extracellular domain (ECD), a 20 aa TM domain and a 98 aa cytoplasmic domain. The ECD includes one C2-type Ig-like domain and two potential N-linked glycosylation sites. Tyrosine phosphorylation of two cytoplasmic ITIM motifs results in recruitment of phosphatases and downregulation of signaling through activating receptors (2, 3, 5). Crosslinking of LAIR-1 inhibits processes such as B cell receptor-mediated activation, NK cell and T cell cytotoxicity and basophil degranulation (1-3). Four m |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q8BG84 |
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| Catalog # | L1100-01J |
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| Order / More Info | LAIR-1, Recombinant, Mouse (Leukocyte-associated Ig-like Receptor-1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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