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| Product Name | RGS Proteins Inhibitor II, CCG-50014 |
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| Description | Purity ~98% (HPLC). A cell-permeable thiadiazolidinedione compound that acts as a direct, potent, selective and cysteine-reactive irreversible inhibitor of RGS4 over other RGS proteins (IC50=0.03, 0.12, 3.5, 11, >200 and >200uM against RGS4, RGS19, RGS16, RGS8, RGS7 and RGS4Cys- using FCPIA assay, respectively). Shown to block RGS4-Ga0 interaction and repress Ga0-dependent membrane localization of RGS4 in HEK-293T cells with no effect on the intrinsic rate of GTP hydrolysis by Ga0. Suggested to interact with Cys107-RGS8 allosteric regulatory site and display minimal affinity towards papain (IC50>100uM). A reversible inhibitor of RGS Proteins, CCG-63802 is also available. Synonyms: 4-(4-Fluorobenzyl)-2-p-tolyl-1,2,4-thiadiazolidine-3,5-dione |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | RGS Proteins Inhibitor II, CCG-50014 (4-(4-Fluorobenzyl)-2-p-tolyl-1,2,4-thiadiazolidine-3,5-dione) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217741 |
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| Order / More Info | RGS Proteins Inhibitor II, CCG-50014 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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