| 产品详情 |
| Edit |   |
|---|
| Product Name | Cxcl12, Recombinant, Mouse, aa22-89, His-Tag (Stromal Cell-derived Factor 1) |
|---|
| Description | Purity ~90% (SDS-PAGE). Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesi |
|---|
| Size | 10ug, 50ug, 100ug |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 12-O-tetradecanoylphorbol 13-acetate repressed protein 1, TPAR1C-X-C motif chemokine 12, Pre-B cell growth-stimulating factor, PBSF Thymic lymphoma cell-stimulating factor, TLSF |
|---|
| Gene, Accession, CAS # | SwissProt: P40224 |
|---|
| Catalog # | 372924 |
|---|
| Price | |
|---|
| Order / More Info | Cxcl12, Recombinant, Mouse, aa22-89, His-Tag (Stromal Cell-derived Factor 1) from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|