| 产品详情 |
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| Product Name | ARP 100 |
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| Description | Purity >98%. Matrix metalloproteinases (MMPs) belong to a family of proteases that play a crucial role in tissue remodeling and repair by degrading extracellular matrix proteins to enable cell migration. During cancer progression both MMP-2 and MMP-9 play a role in metastatic tumor dispersion and angiogenesis. ARP 100 is a biphenylsulfonamide that acts as a selective inhibitor of MMP-2 demonstrating an IC50 value of 12 nM. Due to its specific zinc binding domain configuration, the inhibitory activity of ARP 100 is significantly less potent towards MMP-1, MMP-3, MMP-7, and MMP-9 (IC50 values are 50, 4.5, 50, and 2 µM, respectively). At 50 nM, ARP 100 suppresses the invasive behavior of HT1080 tumor cells. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-[([1,1'-biphenyl]-4-ylsulfonyl)(1-methylethoxy)amino]-N-hydroxy-acetamide, CAY10609, Matrix Metalloproteinase-2 Inhibitor III, MMP-2 Inhibitor III |
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| Gene, Accession, CAS # | CAS: 704888-90-4 |
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| Catalog # | LS-H6619 |
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| Price | |
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| Order / More Info | ARP 100 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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