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| Product Name | PSMD10, Recombinant, Human, aa1-226, His-SUMO-Tag (26S Proteasome Non-ATPase Regulatory Subunit 10) |
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| Description | Purity ~90% (SDS-PAGE). Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5: PSMC2: PSMC1: PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis. Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independ |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Proteasome 26S Subunit, Non ATPase 10, p28, Gankyrin, 26S proteasome non-ATPase regulatory subunit 10, 26S proteasome regulatory subunit p28 |
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| Gene, Accession, CAS # | SwissProt: O75832 |
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| Catalog # | 374912 |
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| Order / More Info | PSMD10, Recombinant, Human, aa1-226, His-SUMO-Tag (26S Proteasome Non-ATPase Regulatory Subunit 10) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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