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| Product Name | p21 Waf1/Cip1 Blocking Peptide |
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| Description | Highly Purified. Peptide is used to block p21 Waf1/Cip1 Rabbit mAb reactivity in immunohistochemistry protocols. The tumor suppressor protein p21 Waf1/ Cip1 acts as an inhibitor of cell cycle progression. It functions in stoichiometric relationships forming heterotrimeric complexes with cyclins and cyclin-dependent kinases. In association with CDK2 complexes, it serves to inhibit kinase activity and block progression through G1/S (1). However, p21 may also enhance assembly and activity in complexes of CDK4 or CDK6 and cyclin D (2). The carboxy-terminal region of p21 is sufficient to bind and inhibit PCNA, a subunit of DNA polymerase, and may coordinate DNA replication with cell cycle progression (3). Upon UV damage or during cell cycle stages when cdc2/cyclin B or CDK2/cyclin A are active, p53 is phosphorylated and upregulates p21 transcription via a p53 responsive element (4). Protein levels of p21 are downregulated through ubiquitination and proteasomal degradation (5). Quality Contr |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | IHC |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | P1000-63 |
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| Order / More Info | p21 Waf1/Cip1 Blocking Peptide from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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