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| Product Name | NSMCE1, Recombinant, Human, aa1-266, His-Tag (Non-structural maintenance of chromosomes element 1 homolog) |
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| Description | Purity ~95% (SDS-PAGE). NSMCE1 is a component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). NSMCE1 has in vitro ubiquitin ligase activity in presence of NDNL2. Source: Recombinant protein corresponding to aa1-266 of human NSMCE1, fused to His-tag at N-terminal expressed in E. coli. Molecular Weight: ~33kD AA |
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| Size | 100ug, 500ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NP_659547 |
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| Catalog # | 350135 |
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| Order / More Info | NSMCE1, Recombinant, Human, aa1-266, His-Tag (Non-structural maintenance of chromosomes element 1 homolog) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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