| 产品详情 |
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| Product Name | AS-041164 |
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| Description | Purity >98%. The phosphatidylinositol 3-kinases (PI3Ks) are lipid and protein kinases involved in diverse biological processes, including cell growth, migration, and metabolism. AS-041164 is a potent inhibitor of PI3K with selectivity for the class IB isoform PI3KGamma (IC50 = 70 nM), compared to PI3KAlpha (IC50 = 240 nM), PI3KBeta (IC50 = 1.45 µM), and PI3KDelta (IC50 =1.70 µM). When tested at 1.0 µM, it shows little or no activity against 38 other common kinases. When given orally to mice, AS-041164 shows a pharmacokinetic profile that is similar to the general PI3K inhibitor LY294002 but is three times more potent (ED50 = 27.4 mg/kg for AS-041164 versus 81.6 mg/kg for LY294002) in blocking neutrophil recruitment induced by RANTES. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5-(1,3-benzodioxol-5-ylmethylene)-2,4-thiazolidinedione |
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| Gene, Accession, CAS # | CAS: 6318-41-8 |
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| Catalog # | LS-H6628 |
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| Order / More Info | AS-041164 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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