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| Product Name | AS-1892802 |
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| Description | Purity >98%. AS-1892802 is a potent inhibitor of Rho-associated serine-threonine protein kinases (ROCKs; IC50 s = 122, 52, and 57 nM for human ROCK1, ROCK2, and rat ROCK2, respectively). It is selective for ROCK1 and 2 over a panel of 167 kinases and a panel of 63 ion channels, receptors, and enzymes at a concentration of 10 µM. However, AS-1892802 inhibits protein kinase catalytic subunit (PKACAlpha) and protein kinase X gene (PRKX) with IC50 values of 200 and 325 nM, respectively. AS-1892802 reduces weight imbalance deficits (ED50 = 0.15 mg/kg) in rats in a monoiodoacetate-induced model of non-inflammatory arthritis. It also has analgesic-like effects in a rat model of diabetic neuropathy induced by streptozotocin and reduces cartilage damage and weight imbalance deficits in a rat model of osteoarthritis. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[(1S)-2-hydroxy-1-phenylethyl]-N'-[4-(4-pyridinyl)phenyl]-urea |
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| Gene, Accession, CAS # | CAS: 928320-12-1 |
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| Catalog # | LS-H6626 |
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| Order / More Info | AS-1892802 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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