| 产品详情 |
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| Product Name | AS-1269574 |
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| Description | Purity >97%. GPR119, a glucose-dependent insulinotropic receptor, is a Gs protein-coupled receptor that is expressed in pancreas beta -cells and intestinal L-cells. Activation of GPR119 by the endogenous ligands lyso-phosphatidylcholine and oleoyl ethanolamide increases intracellular cAMP levels and promotes glucose-stimulated insulin secretion. AS-1269574 is an agonist of GPR119 that is effective both in isolated cells and in vivo. It increases cAMP levels in HEK293 cells transfected with human GPR119 (EC50 = 2.5 µM) and glucose-stimulated insulin secretion in mice (100 mg/kg). |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-[[2-(4-bromophenyl)-6-methyl-4-pyrimidinyl]amino]-ethanol |
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| Gene, Accession, CAS # | CAS: 330981-72-1 |
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| Catalog # | LS-H71 |
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| Order / More Info | AS-1269574 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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