| 产品详情 |
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| Product Name | AS-252424 |
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| Description | Purity >95%. Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of Pl at the 3 position to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3 . 1, PI3KGamma is a class 1B PI3K that is composed of a p110 catalytic subunit and a p101 or p84 regulatory subunit, whereas PI3KAlpha, Beta, and Delta are class 1A enzymes composed of p110 and p85 subunits. 4 AS-252424 is a potent inhibitor of phosphatidylinositol-3-kinase PI3K with selectivity for the Gamma isoform. It inhibits human recombinant PI3KGamma, Alpha, Beta, and Delta with IC50 values of 30, 940, 20,000 and 20,000 nM, respectively. 5 AS-252424 also inhibits C5a-mediated phosphorylation of Akt in RAW 264.7 macrophages with an IC50 value of 0.23 µM. In a murine model of peritonitis, AS-252424 inhibited neutrophil recruitment 35% at a dose of 10 mg/kg. 5 |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5-[5-(4-fluoro-2-hydroxy-phenyl)-furan-2-ylmethylene]-thiazolidine-2,4-dione |
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| Gene, Accession, CAS # | CAS: 900515-16-4 |
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| Catalog # | LS-H6629 |
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| Order / More Info | AS-252424 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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