| 产品详情 |
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| Product Name | AS-604850 |
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| Description | Purity >98%. Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of PI at the three position of the inositol ring to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3 . PI3KGamma is a class 1B PI3K that is composed of a p110 catalytic subunit and a p101 or p84 regulatory subunit, whereas PI3KAlpha, Beta, and Delta are class 1A enzymes composed of p110 and p85 subunits. AS-604850 is a selective, ATP-competitive inhibitor of PI3KGamma with IC50 values of 0.25, >20, >20, and 4.5 µM for the human recombinant Gamma, Delta, Beta, and Alpha isoforms, respectively. AS-604850 inhibited MCP-1-mediated monocyte chemotaxis with an IC50 value of 21 µM and reduced RANTES-induced peritoneal neutrophil recruitment in a murine model of leukocyte chemotaxis with an ED50 value of 42.4 mg/kg. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5-[(2,2-difluoro-1,3-benzodioxol-5-yl)methylene]-2,4-thiazolidinedione |
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| Gene, Accession, CAS # | CAS: 648449-76-7 |
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| Catalog # | LS-H6631 |
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| Order / More Info | AS-604850 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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