| 产品详情 |
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| Product Name | AS-605240 |
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| Description | Purity >98%. Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of phosphatidylinositol at the three position to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3 . PI3KGamma is a class 1B PI3K that is composed of a p110 catalytic subunit and a p101 or p84 regulatory subunit, whereas PI3KAlpha, Beta, and Delta are class 1A enzymes composed of p110 and p85 subunits4 AS-605240 is an orally active inhibitor of PI3-kinase Gamma that suppresses joint inflammation in mouse models of rheumatoid arthritis. It inhibits human recombinant PI3KGamma, Alpha, Beta, and Delta in an ATP-competitive manner with IC50 values of 8, 60, 270, and 300 nM, respectively. AS-605240 inhibits C5a-mediated phosphorylation of protein kinase B in RAW 264 cells with an IC50 value of 90 nM. In vivo, AS-605240 reduced RANTES-induced peritoneal neutrophil recruitment in a mouse model of leukocyte chemotaxis with an ED50 value of 9.1 mg/kg. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5-(6-quinoxalinylmethylene)-2,4-thiazolidinedione |
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| Gene, Accession, CAS # | CAS: 648450-29-7 |
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| Catalog # | LS-H6630 |
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| Order / More Info | AS-605240 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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