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| Product Name | VAP1, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE, reducing conditions). Vascular adhesion protein-1 (VAP1) is a copper amine oxidase with a topaquinone cofactor. VAP1 is a Type II integral membrane protein, but a soluble form of the enzyme is present in human serum, and its level increases in diabetes and some inflammatory liver diseases. VAP1 catalyzes the oxidative deamination of small primary amines such as methylamine, benzylamine, and aminoacetone in a reaction that produces an aldehyde, ammonia, and H2O2. The enzyme is sensitive to inhibition by semicarbazide. VAP1 expression is highest in the endothelium of lung, heart, and intestine, but low in tissues such as brain, spleen, kidney, and liver. VAP1 vascular expression is regulated at sites of inflammation through its release from intracellular granules in which the protein is stored. The adhesive function of VAP1 has been demonstrated in studies showing that the protein is important for the adherence of certain lymphocyte subtypes to inflamed endothelial |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | VAP1, Recombinant, Human (Vascular Adhesion Protein 1, Membrane Primary Amine Oxidase, Copper Amine Oxidase, HPAO, Semicarbazide-sensitive Amine Oxidase, SSAO, VAP-1, AOC3) |
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| Gene, Accession, CAS # | SwissProt: Q16853 |
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| Catalog # | V2095-02F |
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| Order / More Info | VAP1, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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