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| Product Name | Caspase-3/7 Inhibitor I |
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| Description | Purity >98%. Caspase-3/7 inhibitor I is a potent, reversible, isatin sulfonamide-based inhibitor of caspase-3 (Ki (app) = 60 nM; IC50 = 120 nM) and caspase-7 (Ki (app) = 170 nM). It is a weaker inhibitor of caspase-9 (Ki (app) = 3.1 µM) and caspase-1, caspase-2, caspase-4, caspase-6, and caspase-8 (Ki (app)s =25 µM). Caspase-3/7 inhibitor I inhibits apoptosis in camptothecin-treated Jurkat cells (IC50 = ~50 µM) and in chondrocytes (44% inhibition at 10 µM and 98% inhibition at 50 µM). The basis for the unique selectivity of this compound for caspases 3 and 7 involves the recognition of three distinct hydrophobic residues in the S2 pocket surrounding the catalytic cysteine residue. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5-[[2-(methoxymethyl)-1-pyrrolidinyl]sulfonyl]-1H-indole-2,3-dione |
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| Gene, Accession, CAS # | CAS: 1110670-49-9 |
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| Catalog # | LS-H7009 |
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| Price | |
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| Order / More Info | Caspase-3/7 Inhibitor I from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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