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| Product Name | RAD51 Inhibitor, RI-1 (3-chloro-1-(3,4-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione) |
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| Description | Purity ~99% (HPLC). A cell-permeable 1H-Pyrrole-2,3-dione derivative that covalently binds to RAD51 at Cys319 and irreversibly destabilizes a protein-protein interface that is essential for filament formation and recombinase activity. Stimulates single strand annealing at a 5-30uM concentration. Inhibits subnuclear RAD51 foci formation following DNA damage without affecting replication protein A. Also, effectively sensitizes cancer cells to mitomycin C (~25uM) and generate synergistic cell kill in RAD51C mutant cells and with lesser effect on RAD51 complemented cells. Satisfies all four Lipinski rules for predicting drug likeness. Formula: C14H11Cl3N2O3 Molecular Weight: 361.6 Solubility: DMSO (50mg/ml) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217734 |
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| Order / More Info | RAD51 Inhibitor, RI-1 (3-chloro-1-(3,4-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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