| 产品详情 |
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| Product Name | GSK137647A |
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| Description | Purity >97%. GPR120 (Free Fatty Acid Receptor 4; FFAR4) is a G protein-coupled receptor expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids. GSK137647A is a diarylsulfonamide that acts as a selective agonist of GPR120 (pEC50s = 6.3, 6.2, and 6.1 at human, mouse, and rat receptors, respectively). It is selective for GPR120 over a panel of 61 other targets, including other FFARs. Like the natural GPR120 ligand linoleic acid, GSK137647A dose-dependently stimulates insulin secretion by mouse insulinoma MIN6 cells under high glucose conditions. It also modestly stimulates the production of glucagon-like peptide-1 in taste bud cells and human intestinal NCI-H716 cells. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-methoxy-N-(2,4,6-trimethylphenyl)-benzenesulfonamide |
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| Gene, Accession, CAS # | CAS: 349085-82-1 |
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| Catalog # | LS-H146 |
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| Price | |
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| Order / More Info | GSK137647A from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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