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| Product Name | GSK2578215A |
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| Description | Purity >98%. GSK2578215A is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 8.9 nM) that also inhibits the G2019S mutant of LRRK2 (IC50 = 10.1 nM). It displays selectivity for LRRK2 over a panel of 460 other kinases. GSK2578215A prevents phosphorylation of both wild-type and G2019S LRRK2 in mouse spleen and kidney, but not in brain, following intraperitoneal injection of 100 mg/kg. GSK2578215A induces protective autophagy in SH-SY5Y cells and blocks LRRK2-dependent Na+ /Ca2+ exchanger activity in dendritic cells. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5-(2-fluoro-4-pyridinyl)-2-(phenylmethoxy)-N-3-pyridinyl-benzamide |
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| Gene, Accession, CAS # | CAS: 1285515-21-0 |
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| Catalog # | LS-H7996 |
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| Order / More Info | GSK2578215A from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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