| 产品详情 |
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| Product Name | ASIC Channel Modulator II, GMQ |
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| Description | Purity ~99% (HPLC). A positively charged guanidium-containing quinazoline that modulates ASIC function by blocking acid-induced maximal peak current as well as by altering ASICs pH dependence for activation and inactivation, enabling a partial, but sustained ASIC3 activation around neutral pH (4.4% of pH 5-induced peak current with 1mM GMQ at pH 7.4), which is inhibitable by Amiloride. Intraplantar paw injection (10ul 100uM) is reported to elicit a pain response in asic3+/+, but not asic3-/-, mice in vivo. GMQ targeting area appears to overlap with Amiloride binding site in the pore region, but is distinct from ASIC calcium binding site. Solubility: DMSO Primary Target: ASIC3 |
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| Size | 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ASIC Channel Modulator II, GMQ (2-guanidine-4-methylquinazoline, Acid-sensing Ion Channel Modulator II) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217191 |
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| Order / More Info | ASIC Channel Modulator II, GMQ from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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