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| Product Name | MELK, Recombinant, Human, aa1-550, GST-Tag (Maternal Embryonic Leucine Zipper Kinase, HPK38, KIAA0175) |
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| Description | Purified (~70-90%). MELK or maternal embryonic leucine zipper kinase is a member of the CAMKL kinase family. MELK is a key regulator of the proliferation of malignant brain tumors including their stem cells. MELK transcript abundance correlates with malignancy grade in human astrocytomas and represents a therapeutic target for the management of the most frequent brain tumors in adult and children. MELK also plays a role in mammary carcinogenesis through inhibition of the pro-apoptotic function of Bcl-GL. Therefore, the kinase activity of MELK could be a promising molecular target for development of therapy for patients with breast cancers. Source: Recombinant protein corresponding to aa1-550 from human MELK, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~88kD Specific Activity: 210nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NM_014791 |
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| Catalog # | 500253 |
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| Order / More Info | MELK, Recombinant, Human, aa1-550, GST-Tag (Maternal Embryonic Leucine Zipper Kinase, HPK38, KIAA0175) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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