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| Product Name | Phospholipase A2, Lipoprotein Associated (LpPLA2) Recombinant, Human |
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| Description | Purity ≥95%; Endotoxin (LAL): ≤1EU/ug. Lipoprotein-associated phospholipase A2 (Lp-PLA2) also known as platelet-activating factor acetylhydrolase (PAF-AH) is a phospholipase A2 enzyme that in humans is encoded by the PLA2G7 gene. Lp-PLA2 is a 45kD protein of 441 amino acids. It is one of several PAF acetylhydrolases. In the blood it travels mainly with low-density lipoprotein (LDL). Less than 20% is associated with high-density lipoprotein HDL. It is an enzyme produced by inflammatory cells and hydrolyzes oxidized phospholipids in LDL. Lp-PLA2 is platelet-activating factor (PAF) acetylhydrolase (EC 3.1.1.47), a secreted enzyme that catalyzes the degradation of PAF to inactive products by hydrolysis of the acetyl group at the sn-2 position, producing the biologically inactive products LYSO-PAF and acetate.[4] Lp-PLA2 is involved in the development of atherosclerosis, an observation that has prompted interest as a possible therapeutic target (see, e.g. the investigational drug Darapladib |
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| Size | 10ug, 50ug, 200ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q13093 |
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| Catalog # | 156330 |
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| Order / More Info | Phospholipase A2, Lipoprotein Associated (LpPLA2) Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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