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| Product Name | Recombinant Human Ubiquitin thioesterase OTUB1 |
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| Description | 2-201aa; Partial. MW: 50.5kD. Purity >90% as determined by SDS-PAGE. Hydrolase that can specifically rove 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell aner |
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| Size | 0.01 mg, 0.05 mg, 0.1 mg, 0.2 mg, 0.5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [Deubiquitinating enzyme OTUB1OTU domain-containing ubiquitin aldehyde-binding protein 1; Otubain-1; hOTU1; Ubiquitin-specific-processing protease OTUB1] |
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| Gene, Accession, CAS # | OTUB1, Gene ID: 55611, Accession: NP_060140.2 |
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| Catalog # | MBS717257 |
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| Order / More Info | Recombinant Human Ubiquitin thioesterase OTUB1 from MYBIOSOURCE INC. |
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| Product Specific References | Otubainsa new family of cysteine proteases in the ubiquitin pathway.Balakirev M.Y., Tcherniuk S.O., Jaquinod M., Chroboczek J.EMBO Rep. 4:517-522(2003) Two isoforms of otubain 1 regulate T cell anergy via GRAIL.Soares L., Seroogy C., Skrenta H., Anandasabapathy N., Lovelace P., Chung C.D., Engleman E., Fathman C.G.Nat. Immunol. 5:45-54(2004) Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34 hematopoietic stem/progenitor cells.Z |
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