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| Product Name | Recombinant Human Kynurenine 3-monooxygenase |
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| Description | 1-486aa; Full Length. MW: 71.8kD. Purity >90% as determined by SDS-PAGE. Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, |
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| Size | 0.01 mg (E-Coli), 0.05 mg (E-Coli), 0.1 mg (E-Coli), 0.05 mg (Yeast), 0.2 mg (Yeast) |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [Kynurenine 3-hydroxylase ] |
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| Gene, Accession, CAS # | KMO, Gene ID: 8564, Accession: NP_003670.2 |
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| Catalog # | MBS1119330 |
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| Order / More Info | Recombinant Human Kynurenine 3-monooxygenase from MYBIOSOURCE INC. |
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| Product Specific References | Cloning and functional expression of human kynurenine 3-monooxygenase.Alberati-Giani D., Cesura A.M., Broger C., Warren W.D., Rover S., Malherbe P.FEBS Lett. 410:407-412(1997) Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase.Breton J., Avanzi N., Magagnin S., Covini N., Magistrelli G., Cozzi L., Isacchi A.Eur. J. Biochem. 267:1092-1099(2000) Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase.Breton J. |
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