| 产品详情 |
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| Product Name | JNK Inhibitor II |
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| Description | Purity ≥98% by HPLC. A potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50=40nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-y, TNF-a, and COX-2 in cells. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription. JNK Inhibitor II, CAS 129-56-6, is a cell-permeable, potent, selective, ATP-competitive, and reversible inhibitor of c-Jun N-terminal kinase (IC50 = 40 nM for JNK-1 & 2 & 90 nM for JNK-3). Alternate Names: Anthra[1,9-cd]pyrazol-6(2H)-one, 1,9-pyrazoloanthrone, SP600125, SAPK Inhibitor II |
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| Size | 5mg, 25mg, 50mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | JNK Inhibitor II (Anthra[1,9-cd]pyrazol-6(2H)-one, 1,9-pyrazoloanthrone, SP600125, SAPK Inhibitor II) |
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| Gene, Accession, CAS # | CAS: 129-56-6 |
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| Catalog # | 29523 |
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| Order / More Info | JNK Inhibitor II from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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